2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid - Names and Identifiers
2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid - Introduction
2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid is an organic compound with the chemical formula C10H6F6O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless or white crystalline powder
-Solubility: Soluble in organic solvents, such as ether, chloroform, slightly soluble in water
-Melting point: about 55-60 ℃
-Stability: relatively stable at room temperature, avoid prolonged exposure to light and high temperature
Use:
- 2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid can be used as a pharmaceutical intermediate for the synthesis of organic compounds containing phenylacetic acid groups.
-It can also be used as a pesticide intermediate, such as for the synthesis of certain pesticides and herbicides.
Method:
A common method for synthesizing 2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid is as follows:
1. First, benzyl alcohol and trifluoroformic acid were randomly added into the reaction flask.
2. Add sulfoxide as a solvent, and heat the reaction flask to increase the temperature to about 140°C.
3. After a period of reaction, 2,2-bis (3-(trifluoromethyl) phenyl) acetic acid sulfoxide Ester is produced.
4. Finally, the sulfoxide Ester was treated with aqueous acetic acid to give 2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid.
Safety Information:
- 2,2-difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid has a certain irritation, direct contact may cause eye, skin and respiratory tract irritation, therefore, appropriate protective measures should be taken during use.
-It should be kept away from fire sources, heat sources and oxidants, and stored in a dry and well-ventilated place.
-If inhaled or swallowed, seek help from your doctor immediately and provide your chemical name and related information.
Last Update：2024-04-09 21:00:56